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NVMe drives are exclusively compatible with the M.2 slot on a motherboard. It is essential to verify if your motherboard has any M.2 slots.
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What is the most amount of NVMe SSDs that one motherboard can support? - Quora
Answer (1 of 2): On just the motherboard? Well, there is a $1,000 motherboard for AMD Threadripper with 5 M.2 slots. The ASUS ROG Zenith II Extreme Alpha.
It's got 4 PCIe slots, and I think you could use an NVMe in three of those, with one for a GPU.
So I think eight woukd be about the max. May...